论文部分内容阅读
目的探讨不同类型冠心病患者血清可溶性OX40配体(sOX40L)和C反应蛋白(Creactive protein,CRP)水平的临床意义。方法分别采用ELISA法和免疫透射比浊法检测458例疑似或诊断为冠心病患者血清sOX40L和CRP的浓度,采用冠脉造影术和ACC/AHA评分法判定冠状动脉病变程度。结果急性冠脉综合征(ACS)组患者血清sOX40L和CRP水平及冠脉评分均明显高于稳定型心绞痛(SAP)组和正常对照(CT)组(P<0.01);sOX40L与CRP及冠脉评分均呈正相关(P<0.01),CRP与冠脉评分亦呈正相关(P<0.01)。结论血清sOX40L和CRP水平与冠心病患者的病情严重程度及冠状动脉病变程度密切相关,sOX40L有望与CRP一样,作为炎症指标预测冠心病的发生和预后。
Objective To investigate the clinical significance of serum soluble OX40 ligand (sOX40L) and C reactive protein (CRP) in patients with different types of coronary heart disease. Methods Serum levels of sOX40L and CRP in 458 patients with suspected or diagnosed CHD were detected by ELISA and immunoturbidimetry respectively. The degree of coronary artery lesion was determined by coronary angiography and ACC / AHA score. Results The levels of sOX40L and CRP and the scores of coronary artery in patients with acute coronary syndrome (ACS) were significantly higher than those in patients with stable angina (SAP) and normal controls (P <0.01). The levels of sOX40L, CRP and coronary (P <0.01). There was also a positive correlation between CRP and coronary artery score (P <0.01). Conclusion Serum levels of sOX40L and CRP are closely related to the severity of coronary artery disease and severity of coronary artery disease. SOX40L is expected to predict the occurrence and prognosis of coronary artery disease as an index of inflammation.