胰岛素抵抗(Insulin resistance,IR)是指胰岛素靶组织器官(肝脏、肌肉、脂肪组织等)对胰岛素生理反应的敏感度降低,需要较高的胰岛素分泌水平才能维持胰岛素正常生理功能,高胰岛素血症和继发的胰岛素分泌相对或绝对不足将产生一系列代谢病理生理变化。IR是由先天性遗传因素与后 Insulin resistance (IR) refers to the reduced sensitivity of insulin target tissues and organs (liver, muscle, adipose tissue, etc.) to the physiological response of insulin. It requires a high level of insulin secretion to maintain the normal physiological function of insulin and hyperinsulinemia And secondary insulin secretion relative or absolute lack of will produce a series of metabolic pathophysiological changes. IR is caused by congenital hereditary factors