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【目的】研究早期综合干预对早产低体重儿生后早期追赶生长及胰岛素敏感性的影响,以提高早产儿健康水平。【方法】将2008年1月—2009年2月在本院新生儿科住院的早产儿作为研究对象,按家长是否同意接受早期综合干预分为早期干预组和对照组。早期干预组:1)家长或抚养人参加科学育儿学习班;2)每天给婴儿做抚触、被动操、洗澡、游泳、晒太阳,尽可能与婴儿视觉交流、语言交流、提供适当的玩具等。对照组:不接受婴儿抚触等早期干预措施,常规育儿。两组婴儿满3个月时来院查体,查体内容包括:1)家长填写育儿问卷;2)测量婴儿体重、身长、头围;3)化验血常规、血胰岛素、血糖。用内稳态模式评估公式(HOMA)评价胰岛素敏感性。【结果】1)3个月时干预组体重、身长、头围的变化值(△SDS)与对照组比较差异有高度统计学意义(P<0.01);2)3个月时干预组血胰岛素敏感性较对照组明显增高(P<0.01)。【结论】早期综合干预能促进早产儿胃肠功能发育,提高早产儿血胰岛素敏感性,促进早产儿生后早期追赶生长。
【Objective】 To investigate the effect of early comprehensive intervention on the catch-up growth and insulin sensitivity in preterm infants with low birth weight preterm to improve the health of premature infants. 【Methods】 The premature infants hospitalized in neonatal department of our hospital from January 2008 to February 2009 were divided into the early intervention group and the control group according to whether the parents agreed to accept the early comprehensive intervention. Early intervention group: 1) parents or caregivers participate in scientific childcare classes; 2) touch the baby every day, passive exercise, bathing, swimming, sun exposure, visual communication with babies as much as possible, language exchange, providing appropriate toys, etc. . Control group: do not accept infants touch early intervention, routine child care. The two groups of infants came to the hospital at least 3 months after examination. The physical examination contents include: 1) parents fill in the questionnaire for childcare; 2) measure the baby’s weight, length and head circumference; 3) test blood, blood insulin and blood sugar. Insulin sensitivity was assessed using the homeostasis model assessment formula (HOMA). 【Results】 1) At 3 months, the changes of body weight, body length and head circumference (△ SDS) in the intervention group were highly statistically significant compared with the control group (P <0.01); 2) At 3 months, Sensitivity was significantly higher than the control group (P <0.01). 【Conclusion】 The early comprehensive intervention can promote the development of gastrointestinal function in premature infants, increase the blood insulin sensitivity in premature infants, and promote the early catch-up growth of premature infants.