目的:雌激素可促进乳腺癌转移,但其分子机制尚未阐明。Ezrin为肌动蛋白结合蛋白,其激活可引发肌动蛋白骨架重构(actin cytoskeleton remodeling),促进多种肿瘤组织的转移。本研究拟探讨Ezrin蛋白在雌激素促进乳腺癌细胞迁移和侵袭中的作用及其分子机制。方法:在培养的人乳腺癌细胞株T47-D上,免疫荧光法观察磷酸化Ezrin蛋白和细胞 Objective: Estrogen can promote breast cancer metastasis, but its molecular mechanism has not been elucidated. Ezrin is an actin-binding protein whose activation initiates actin cytoskeleton remodeling and promotes the metastasis of various tumor tissues. This study was to explore the role of Ezrin protein in estrogen-induced breast cancer cell migration and invasion and its molecular mechanism. Methods: The cultured human breast cancer cell line T47-D was immunostained for the phosphorylation of Ezrin protein and cell