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20世纪50年代起环氧乙烷开始用于医院灭菌,国内医疗机构引入环氧乙烷灭菌器始于上世纪90年代中期,主要用于怕热怕湿医疗器械的灭菌。随着环氧乙烷灭菌器在国内的不断普及,环氧乙烷灭菌监测中的问题也引起了广泛的关注。而环氧乙烷灭菌生物指示物的抗力水平在灭菌效果监测中尤为重要。用于环氧乙烷灭菌效果监测的生物指示菌为国际通用菌株,即枯草杆菌黑色变种(ATCC9372)芽孢,其生物学特性是易于培养与保存、在固
Since the 1950s, ethylene oxide began to be used for hospital sterilization. The introduction of ethylene oxide sterilizers by domestic medical institutions began in the mid-1990s and was mainly used for the sterilization of wet medical devices. With the continuous popularization of ethylene oxide sterilizers in China, the problems in the ethylene oxide sterilization monitoring have also drawn wide attention. The resistance level of ethylene oxide sterilization bio-indicators is particularly important in the monitoring of sterilization effect. The biological indicator bacteria used for the monitoring of the sterilization effect of ethylene oxide is an international strain of Bacillus subtilis (ATCC 9372) spore, the biological characteristics of which are easy to culture and preserve,