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目的:观察α-硫辛酸治疗2型糖尿病早期肾病的疗效。方法:将60例伴有微量白蛋白尿的2型糖尿病患者随机分成硫辛酸治疗组(治疗组)30例和常规治疗组(对照组)30例。对照组予以控制饮食、降糖、降压等基础治疗,治疗组在对照组基础上加用硫辛酸注射液,治疗前后测定24小时尿微量白蛋白排泄率(UAER)、尿β2微球蛋白水平,比较两组患者的临床治疗效果。结果:与治疗前比较,治疗组UAER及尿β2微球蛋白水平均显著降低(P<0.01),治疗过程中未出现明显不良反应。对照组UAER及尿β2微球蛋白水平与治疗前比较差异无统计学意义(P>0.05)。结论:α-硫辛酸能减少2型糖尿病肾病(DN)患者24小时尿微量白蛋白的排泄及尿β2微球蛋白水平,对早期糖尿病肾病有保护作用。
Objective: To observe the therapeutic effect of α-lipoic acid on type 2 diabetic nephropathy. Methods: Sixty diabetic patients with type 2 diabetes mellitus with microalbuminuria were randomly divided into three groups: 30 in the lipoic acid treatment group (treatment group) and 30 in the conventional treatment group (control group). The control group was given basic treatment such as diet, hypoglycemic and antihypertensive treatment. The treatment group was given lipoic acid injection on the basis of the control group, 24 hours urinary albumin excretion rate (UAER) and urinary β2 microglobulin level , Comparing the clinical treatment effect of two groups of patients. Results: Compared with those before treatment, the levels of UAER and urinary β2 microglobulin in the treatment group were significantly decreased (P <0.01), and no obvious side effects occurred during the treatment. There was no significant difference in UAER and urinary β2 microglobulin levels between the control group and before treatment (P> 0.05). CONCLUSION: Alpha-lipoic acid can reduce 24-hour urinary albumin excretion and urinary β2 microglobulin levels in patients with type 2 diabetic nephropathy (DN), which may have protective effects on early diabetic nephropathy.