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1985年7月5日至19日在西德汉堡举行的世界第十二届病毒相关疾病会议,从会议得知前S基因的研究可能改变乙肝疫苗的研制方向。目前已建立了可产生前S基因的细胞系。前S基因编码P25多肽NH_2末端的33/36KD糖蛋白,此多肽由55个氨基酸组成,决定乙肝疫苗免疫效果。含有前S基因编码的乙肝疫苗的免疫效果是不含此编码的乙肝疫苗免疫效果的4倍。前
The twelfth conference on virus-related diseases held in Hamburg, West Germany, from July 5 to 19, 1985, learned from the conference that the study of pre-S gene might change the direction of development of hepatitis B vaccine. Currently, cell lines that produce pre-S genes have been established. The former S gene encodes the 33/36 KD glycoprotein at the NH2 terminus of the P25 polypeptide, which consists of 55 amino acids and determines the immunogenicity of the hepatitis B vaccine. The immune effect of the hepatitis B vaccine containing the pre-S gene is 4 times that of the hepatitis B vaccine without this code. before