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目的:考察冰片、薄荷醇、氮酮3种促渗剂联合应用对乳炎清凉巴布剂体外透皮吸收的影响,确定其最优组合。方法:利用ZTY-型透皮扩散仪,以乳牛皮肤为材料,采用三因素三水平正交试验设计,以HPLC法检测乳炎清凉巴布剂主要成分绿原酸在不同时间的透皮含量,计算各组透皮吸收速率、累积渗透量等。结果:9个试验组均有绿原酸透皮吸收,组间有显著性差异,其中A1B1C2(冰片∶薄荷醇∶氮酮为1%∶1%∶3%)为最优组合。结论:冰片、薄荷醇、氮酮3种促渗剂按1%、1%、3%联合应用能显著促进乳炎清凉巴布剂中绿原酸的透皮吸收。
OBJECTIVE: To investigate the effects of combination of three kinds of penetration enhancers, borneol, menthol and azone on the transdermal absorption of lactobacillus in vitro and to determine their optimal combination. Methods: ZTY-type transdermal diffuser was used to measure the transdermal content of chlorogenic acid, which is the main component of the mastitis cool cataplasma, at different times by using orthogonal design of three factors and three levels. Calculate the transdermal absorption rate of each group, the cumulative amount of penetration and so on. Results: There were significant differences in transdermal absorption of chlorogenic acid between the nine experimental groups. The optimal combination of A1B1C2 (borneol: menthol: azone) was 1%: 1%: 3%. CONCLUSION: The combination of borneol, menthol, and azone with 1%, 1% and 3% respectively can significantly promote the transdermal absorption of chlorogenic acid in the lamivudine cataplasm.