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用异丙肾上腺素 ( Iso)诱发豚鼠右心室乳头肌产生早后除极 ( EAD)和触发活动 ( TA) ,通过细胞内微电极技术 ,观察双苯氟嗪 ( Dip)对 EAD和TA的预防作用 .在 0 .5Hz刺激频率下 ,50 nmol· L-1Iso在延长动作电位时程的基础上 ,可诱发豚鼠乳头肌产生 EAD,并出现 TA,有时 TA会发展成持久的节律性活动 ,有的还伴有 EAD或迟后除极 . Dip 3和 1 0μmol· L-1可显著降低 Iso诱发的 EAD波幅及发生率和 TA发生率 ;Dip1 0 μmol·L-1还明显延长 TA潜伏期 .结果提示 ,Dip能预防 ,减少或延迟 Iso引起的豚鼠乳头肌 EAD和TA.
Isolation of early and late depolarization (EAD) and triggering activity (TA) of guinea pig papillary muscles was induced by isoproterenol (Iso), and the prevention of EAD and TA by Diphenhydramine was studied by intracellular microelectrode technique At the frequency of 0.5Hz, 50 nmol · L-1Iso could induce EAD and TA in guinea pig papillary muscles on the basis of prolonging the action potential duration, and sometimes TA would develop into long-lasting rhythmic activity with Were also accompanied by EAD or delayed depolarization.Dip 3 and 10 μmol · L-1 significantly reduced the amplitude of Iso-induced EAD and the incidence of TA and the incidence of TA. Dip1 0 μmol·L-1 also significantly prolonged the latency to TA. Tip, Dip can prevent, reduce or delay Iso-induced guinea pig papillary muscle EAD and TA.