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目的:分析头孢菌素类抗生素致不良反应发生的原因及其救治对策。方法:选取2013年4月—2015年3月间就诊并给予头孢菌素类抗生素治疗的900例患者,采用回顾性分析法,分析头孢菌素类抗生素致不良反应发生原因及救治措施。结果:900例头孢菌素类抗生素使用患者中,28例患者发生不良反应症状,其不良反应发生率为3.11%;且过敏史阳性患者对头孢菌素类抗生素的总不良反应发生率明显高于过敏史阴性患者(χ~2=15.75,P<0.05);头孢菌素类抗生素所致不良反应症状主要包括变态反应、胃肠道反应等,其中变态反应的发生率相对较高,占所有不良反应的46.43%。结论:头孢菌素类抗生素在临床使用中需加强对不良反应的监测,一旦发现异常应及时处理,避免不良反应所导致的严重后果,不利于患者的预后恢复。
Objective: To analyze the causes of adverse reactions caused by cephalosporin antibiotics and its treatment strategies. Methods: A total of 900 patients who were treated with cephalosporin antibiotics from April 2013 to March 2015 were retrospectively analyzed. The causes and treatment of adverse reactions caused by cephalosporins were analyzed. Results: Of the 900 cephalosporin antibiotics used, 28 patients developed adverse reactions and the rate of adverse reactions was 3.11%. The incidence of adverse reactions to cephalosporins was significantly higher in patients with positive allergy history Allergic history of negative patients (χ ~ 2 = 15.75, P <0.05); cephalosporin antibiotic-induced adverse reactions include allergy, gastrointestinal reactions, etc., of which the incidence of allergy is relatively high, accounting for all adverse 46.43% of the reaction. Conclusion: Cephalosporin antibiotics need to be strengthened in clinical use to monitor adverse reactions. Once the abnormalities are detected, they should be treated promptly to avoid serious consequences caused by adverse reactions, which is not conducive to the prognosis of patients.