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为预防手术时创伤感染等较严重的感染,常使用抗生素。特别是最近由于新抗生素的较强抗菌作用,使肠内菌丛变化,或因某种新的抗生素作用于血液凝固因子在肝脏的合成系统,由于维生素K 缺乏,导致低凝血酶原血症。因此,重要的是注意术后出血的危险性,或弥漫性出血倾向及出现消化道出血等。作者所在医院外科手术较长时间投用抗生素时,以控制上述危险性在最小限度为目的,并用维生素K_2,本文汇集有关这些病例的血液凝固机能的检验结果,加以统计学处理报告如下:
Antibiotics are often used to prevent more serious infections such as traumatic infections during surgery. Especially recently, due to the strong antibacterial effect of new antibiotics, intestinal flora changes, or because of some new antibiotics acting on the blood clotting factor in the liver synthesis system, due to lack of vitamin K, leading to low prothrombinmia. Therefore, it is important to pay attention to the risk of postoperative bleeding, or diffuse bleeding tendency and the emergence of gastrointestinal bleeding. The author’s hospital surgery for a long time when the use of antibiotics, in order to control the above-mentioned risk for the minimum purpose, and vitamin K_2, this article pooled the blood coagulation test results of these cases were statistically treated as follows: