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1.本文就臭梧桐的一般性质作了实验性研究,结果证明其降血压成分易溶于水,难溶或不溶于乙醚、乙醇和氯仿,对热稳定,在碱性溶液中可被氯化钙沉淀出来。臭梧桐降血压效果可因产地而不同。开花前的和新鲜的臭梧桐降血压作用分别较开花后的和经长时间保存的要强。 2.臭梧桐毒性甚小,其热浸剂和提出物给小鼠静脉注射时半数致死量分别为19.4克/公斤和0.98±0.075克/公斤。给大鼠每天用热浸剂(0.25—2.5克/公斤)灌胃经60天,除少数动物出现安静、轻度收缩压下降和大便变稀外,未发现其他毒性反应。 3.臭梧桐提出物(50—100毫克/公斤)和热浸剂(150毫克/公斤)给麻醉大鼠和狗静脉注射时,可引起两度血压下降,但肌肉注射或经口给药,仅引起第二度降血压作用,其作用可维持2—3小时。静脉注射煎剂(麻醉大鼠和狗实验)仅出现第一度降血压作用,经口给药时无效。乙醚、乙醇和氯仿的浸出液不论静脉注射或经口给药,均不引起麻醉动物的血压下降。给肾型高血压大鼠每天经口投予臭梧桐热浸剂(0.5—5克/公斤)和提出物(50毫克/公斤)时,给药的第3—10天卽口出现血压下降,在给药的第二周和停药后的第一周,血压下降最明显,最大降血压作用可达原值的57.4％。多数高血压大鼠的血压在停药后的第二周恢复,少数在停药的2—4天或4周后恢复。
1. An experimental study was conducted on the general properties of Jatropha. The results showed that its blood pressure-lowering component is easily soluble in water, insoluble or insoluble in ether, ethanol, and chloroform. It is stable to heat and can be chlorinated in alkaline solution. Precipitation of calcium. The stinky paulownia blood pressure lowering effect may vary depending on the origin. The blood pressure before and after flowering was higher than that after flowering and after long-term preservation. 2. The toxicity of Ailanthus altissima is very small, and the LD50 for intravenous injection of hot-infusion and extracts to mice is 19.4 g/kg and 0.98±0.075 g/kg, respectively. Rats were given intragastric administration with a hot infusion (0.25-2.5 g/kg) daily for 60 days. Except for a few animals that had a quiet, mild systolic blood pressure drop and stool thinning, no other toxicities were found. 3. When the odoriferous extract (50-100 mg/kg) and the hot infusion (150 mg/kg) are intravenously administered to anesthetized rats and dogs, it can cause a two-fold drop in blood pressure, but it is given intramuscularly or orally. Only cause the second degree of hypotensive effect, its role can be maintained for 2-3 hours. Intravenous decoction (anesthetized rats and dogs) showed only the first degree of hypotensive effect, which was ineffective when administered orally. The leaching of ether, ethanol, and chloroform did not cause blood pressure drop in anesthetized animals regardless of intravenous or oral administration. When kidney hypertensive rats were orally administered daily with oral heat infusion (0.5-5 g/kg) and extract (50 mg/kg), blood pressure decreased during the third to ten days of administration. In the second week of administration and the first week after drug withdrawal, the blood pressure dropped most significantly, and the maximum blood pressure lowering effect was up to 57.4% of the original value. The blood pressure of most hypertensive rats resumed in the second week after discontinuation, and a few recovered within 2-4 days or 4 weeks after drug withdrawal.