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目的：比较氯沙坦钾联合吲达帕胺或马来酸左旋氨氯地平治疗老年高血压的临床疗效。方法选择2013年10月—2014年9月天津港口医院收治的老年高血压患者146例，按随机数字表法分为对照组（70例）与观察组（76例）。对照组患者予以氯沙坦钾联合马来酸左旋氨氯地平治疗，观察组患者予以氯沙坦钾联合吲达帕胺治疗。观察两组患者临床疗效、治疗前后空腹血糖（ FBG）、血清总胆固醇（ TC）、三酰甘油（ TG）、血尿酸（ BUA）、血清钾（K+）水平及不良反应发生情况。结果两组患者总有效率比较，差异无统计学意义（P﹥0.05）；治疗前两组患者 FBG、TC、TG、BUA、K+水平比较，差异无统计学意义（ P﹥0.05），治疗后两组患者 FBG、TC、TG水平比较，差异无统计学意义（ P﹥0.05），观察组患者BUA水平高于对照组，K+水平低于对照组，差异有统计学意义（ P﹤0.05）；两组患者不良反应发生率比较，差异无统计学意义（ P﹥0.05）。结论氯沙坦钾联合吲达帕胺或左旋氨氯地平治疗老年高血压的临床疗效相当，而氯沙坦钾联合吲达帕胺对BUA、K+水平影响小，可作为优选方案。“,”Objective To comPare the effect between Losartan Potassium and IndaPamide or L-AmlodiPine in trea-ting elderly hyPertension. Methods A total of 146 Patients with elderly hyPertension were selected in Gangkou HosPital of Tian-jin from October 2013 to SePtember 2014,according to the random number table,they were divided into control grouP(70 ca-ses) and observation grouP(76 cases). Control grouP were given Losartan Potassium and IndaPamide treatment,observation grouP were given Losartan Potassium and IndaPamide treatment. Clinical effect,before and after treatment fasting blood glucose ( FBG),total cholesterol( TC),triglyceride( TG),blood uric acid( BUA),blood K+( K+) levels and incidence of ad-verse reactions were observed. Results The total effective rate showed no significant differences between the two grouPs( P﹥0. 05);before treatment,FBG,TC,TG,BUA and K+ levels showed no significant differences between the two grouPs( P﹥0. 05),after treatment,FBG,TC,TG levels showed no significant differences between the two grouPs(P﹥0. 05),BUA lev-el of observation grouP was higher than that of control grouP(P﹤0. 05),K+ level was lower than that of control grouP(P﹤0. 05);incidence of adverse reactions showed no significant differences between the two grouPs( P﹥0. 05). Conclusion Losartan Potassium and IndaPamide or L-AmlodiPine in treating elderly hyPertension have quite clinical effect,Losartan Potas-sium and IndaPamide has small imPact on BUA,K+ level,can be used as an oPtimization scheme.