论文部分内容阅读
子痫前期是导致围产期母儿死亡的主要原因,临床上缺乏有效的诊治方法。该病发病机制的核心是早期绒毛外滋养细胞的侵袭不良。基因组印迹与滋养细胞侵袭不良有关,是子痫前期未来研究的重要领域。胰岛素样生长因子(IGF)Ⅱ和H19是一对物理和机能连锁的印迹基因,它们参与滋养细胞的侵袭行为,综述印迹基因IGFⅡ和H19与子痫前期关系的研究现状,探索疾病的表观遗传学发病机制,有助于疾病的临床防治。
Preeclampsia is the leading cause of perinatal maternal death, the clinical lack of effective diagnosis and treatment methods. The pathogenesis of this disease is the core of early extravillous trophoblast invasion. Genomic imprinting is associated with poor trophoblast invasion and is an important area for future research in preeclampsia. Insulin-like growth factors (IGFs) II and H19 are a pair of physically and functionally linked imprinted genes that are involved in the invasion of trophoblasts and review the current status of the relationship between imprinted genes IGF II and H19 and preeclampsia to explore the epigenetic Learn the pathogenesis, contribute to the clinical prevention and treatment of the disease.