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目的:通过测定脑瘫患儿血清胰岛素样生长因子-1(IGF-1)、γ-氨基丁酸(GABA)、谷氨酸(GLU)的含量,探讨IGF-1、GABA、GLU在脑瘫发生发展过程中的作用机制。方法:应用放射免疫法检测脑瘫患儿血清IGF-1含量,应用高效液相色谱法测定脑瘫患儿血清中GLU、GABA含量。结果:1、脑瘫患儿血清IGF-1、GABA含量显著低于对照组(P<0.05),GLU含量显著高于对照组(P<0.05)。痉挛型和手足徐动型患儿血清IGF-1、GLU、GABA含量无显著差别(P>0.05)。2、脑瘫患儿血清GLU与GABA、IGF-1与GLU成负相关,GABA与IGF-1成正相关。结论:IGF-1、GLU、GABA均参与了CP病理生理过程,是反映脑损伤程度的生化指标,并可能参与CP的发病机制。
Objective: To investigate the occurrence and development of cerebral palsy (IGF-1), GABA and GLU in serum of children with cerebral palsy by detecting the levels of serum insulin-like growth factor-1 (IGF-1), gamma-aminobutyric acid (GABA) and glutamic acid (GLU) The role of mechanism in the process. Methods: Serum IGF-1 levels in children with cerebral palsy were detected by radioimmunoassay. Serum levels of GLU and GABA in children with cerebral palsy were measured by high performance liquid chromatography. Serum levels of IGF-1 and GABA in children with cerebral palsy were significantly lower than those in control group (P <0.05), GLU content was significantly higher than that in control group (P <0.05). There was no significant difference in serum IGF-1, GLU, GABA levels in children with spastic and athetosis (P> 0.05). Serum GLU and GABA, IGF-1 and GLU in children with cerebral palsy were negatively correlated, and GABA was positively correlated with IGF-1. CONCLUSION: Both IGF-1, GLU and GABA are involved in the pathophysiology of CP and are biochemical markers reflecting the degree of brain injury and may be involved in the pathogenesis of CP.