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目的:探讨外科手术+全身化疗结合局部植入缓释5-氟脲嘧啶间质化疗药物治疗口腔鳞癌(OSCC)的疗效及安全性。方法:实验组(间质化疗组):33例实施OSCC根治手术及全身静脉化疗,术中植入中人氟安缓释氟尿嘧啶间质化疗药,平均用药剂量为200～400mg;对照组(静脉化疗组)30例OSCC手术结合全身静脉化疗。两组均随访36个月,比较其术后复发率、死亡率以及毒副反应。SPSS统计软件进行统计学分析。结果:随访观察的患者中,实验组术后12、24个月的复发率(6.06%,15.2%)、术后12、24、36个月的死亡率(6.06%,12.1%,24.2%)优于对照组(P<0.05),且其毒副反应与对照组无显著性差异(P>0.05)。结论:手术切除+全身化疗结合局部术区植入缓释氟尿嘧啶间质化疗药物,可以提高肿瘤局部化疗药物的浓度,延长作用时间,在不增加毒副反应的同时提高疗效及生存质量。
Objective: To investigate the efficacy and safety of surgical + systemic chemotherapy combined with local implantation of 5-fluorouracil and interstitial chemotherapy drugs in the treatment of oral squamous cell carcinoma (OSCC). Methods: In the experimental group (interstitial chemotherapy group), 33 patients undergoing OSCC radical surgery and systemic vein chemotherapy were treated with intraoperative fluorouracil-releasing fluorouracil interstitial chemotherapeutic drugs in an average dose of 200-400 mg. The control group (vein Chemotherapy group) 30 cases of OSCC combined with systemic vein chemotherapy. All patients were followed up for 36 months. The recurrence rate, mortality rate and toxicity were compared between the two groups. SPSS statistical software for statistical analysis. Results: The recurrence rate (6.06%, 15.2%) at 12 and 24 months postoperatively, and the death rates at 12, 24 and 36 months (6.06%, 12.1%, 24.2% Which was better than the control group (P <0.05), and its toxicity was not significantly different from the control group (P> 0.05). Conclusion: Surgical resection + systemic chemotherapy combined with local implantation of sustained-release fluorouracil interstitial chemotherapy drugs can increase the concentration of local chemotherapy drugs and prolong the action time without increasing the side effects and improving the curative effect and quality of life.