论文部分内容阅读
用特异性放射免疫分析法测定了74例原发性高血压(EH)患者血浆脑钠素(BNP)水平的变化,结果显示EH组血浆BNP(87.59±5.96pg/ml)的水平明显高于对照组(34.66±2.99pg/ml)(P<0.001),其升高的幅度与高血压的严重程度密切相关。提示在EH时,体内BNP的合成与释放增加,参与了血压的调节,在高血压的发病中具有一定意义。伴脑梗塞及眼底病变严重时,脑内BNP释放增加;有左室肥厚致左室顺应性下降,左房负荷过重,刺激心房肌细胞分泌过多的BNP;肾功能异常者,BNP的降解与排泄减少,均可致血浆BNP水平进一步升高(P<0.01～0.001)。
The levels of plasma BNP in 74 patients with essential hypertension (EH) were measured by specific radioimmunoassay. The results showed that the plasma levels of BNP (87.59 ± 5.96pg / ml) in EH group were significantly higher than those in EH group The control group (34.66 ± 2.99pg / ml) (P <0.001), the magnitude of which is closely related to the severity of hypertension. It is suggested that the synthesis and release of BNP in the body increases at EH, which is involved in the regulation of blood pressure, which is of certain significance in the pathogenesis of hypertension. With severe cerebral infarction and fundus lesions, increased BNP release in the brain; left ventricular hypertrophy caused by decreased left ventricular compliance, left atrial overloaded, stimulated atrial myocyte secretion of excessive BNP; renal dysfunction, degradation of BNP And excretion reduced, can cause plasma BNP levels increased further (P <0.01 ~ 0.001).