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淋巴祖细胞、胸腺上皮细胞、造血干细胞、骨髓基质细胞分别是导致胸腺和骨髓退化的关键因素。另外,胸腺和骨髓的退化也是内皮细胞异质性消退的反映。淋巴细胞通过内皮组织进出胸腺,血窦内皮细胞动员造血干细胞。内皮细胞的异质性受所在微环境调节,可塑性强。微循环伴随神经具有组织特异性,其感觉神经递质的外周分泌作用于内皮细胞,可能调控内皮细胞特异性表达。器官衰老是微循环有序退化的过程,正常生理情况下,胸腺和骨髓退化的调节中微循环及伴随神经的作用可能居优势地位。
Lymphoid progenitor cells, thymus epithelial cells, hematopoietic stem cells, and bone marrow stromal cells are the key factors that cause degeneration of the thymus and bone marrow, respectively. In addition, degeneration of the thymus and bone marrow is also a reflection of endothelial cell heterogeneity. Lymphocytes enter and leave the thymus via the endothelium, and blood sinusoidal endothelial cells mobilize hematopoietic stem cells. The heterogeneity of endothelial cells is regulated by the microenvironment in which they are located, and the plasticity is strong. Microcirculation accompanied by nerve tissue specificity, the sensory neurotransmitter peripheral secretion role in endothelial cells, may regulate endothelial cell-specific expression. Organ aging is an orderly process of microcirculation degeneration, under normal physiological conditions, the regulation of thymus and bone marrow degeneration microcirculation and accompanying nerve may occupy a dominant position.