1982年,Nyman用一种半透性滤膜治疗牙周病,后扩展应用于骨缺损的治疗。1993年,Buser等提出了引导骨再生(guided boneregeneration,GBR)的概念。其原理是根据各类组织细胞迁移速度不同,将屏障膜置于软组织和骨缺损之间建立生物屏障,创造一个相对封闭的组织环境,阻止结缔组织细胞和上皮细胞进入骨缺损区,允许有潜在生长能力、迁 In 1982 Nyman used a semi-permeable filter to treat periodontal disease and later expanded it for the treatment of bone defects. In 1993, Buser et al. Proposed the concept of guided bone regeneration (GBR). The principle is based on the rate of migration of different types of tissue cells, the barrier membrane placed in soft tissue and bone defects to establish a biological barrier between the creation of a relatively closed organizational environment to prevent connective tissue cells and epithelial cells into the defect area, allowing potential Growth ability, relocation