Taizhou Yangtze River Highway Bridge is the first three-pylon two-span suspension bridge in China. The maingirder adopts flat steamline steel closed box girder which has well wind-resistant capability and is technically mature besides beautiful appearance. Straight web plates of the steel box girder in longitudinal direction are proposed in order to ensure the integrity of the steel box girder, and to keep the stress of the steel box girder continuous in the middle pylon,as well as to reduce the gradient of the middle pylon columns. The cross section of the box girder has one box with three cells. Solid-web diaphragm plate with good integrity and high torsional stiffness is adopted. The lifting lugs are utilized in the anchors of suspender cable. In this paper, selection of the cross section of the steel box girder, the general structure design, local structure design and main structure calculation results of Taizhou Yangtze River Bridge are introduced emphatically.