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本文研究异搏停与硝苯吡啶对原发性高血压患者及正常人的血压、心率、血浆儿茶酚胺、血浆肾素活性、血容量及心功能的短期与长期影响。方法:53例原发性高血压患者,男32例,女21例,年龄22～53岁,平均38岁,按WHO分期为Ⅰ期或Ⅱ期。15例血压正常的健康志愿者,男9例,女6例,年龄24～41岁,平均30岁。采用三种方案进行研究:(1)急性研究:单盲法一次给予异搏定160毫克口服或硝苯吡啶10毫克舌下含化后,每15分钟测量一次血压、心率,给药前和给药后30′,60′、120′、180′测定血浆肾素活性、去甲肾上腺素及肾上腺素浓度。(2)对照研究:先予异搏定80毫克一日3次口服8天,间歇5天后,再予硝苯吡啶10毫克一日3次口服8天,或顺序倒过来应用,皆单盲法给药。试验期间摄入固定钠钾含量的欲
This study was to investigate the short-term and long-term effects of verapamil and nifedipine on blood pressure, heart rate, plasma catecholamine, plasma renin activity, blood volume and cardiac function in patients with essential hypertension and normal subjects. Methods: 53 patients with essential hypertension, 32 males and 21 females, aged 22 to 53 years, mean 38 years, according to WHO stage Ⅰ or Ⅱ. 15 healthy volunteers with normal blood pressure, 9 males and 6 females, aged from 24 to 41 years, with an average of 30 years. Three studies were conducted: (1) Acute study: once a single blinded test given Veratropin 160 mg orally or nifedipine 10 mg sublingually, blood pressure and heart rate were measured every 15 minutes before administration and The plasma renin activity, norepinephrine and epinephrine concentration were measured at 30 ’, 60’, 120 ’and 180’ after drug administration. (2) control study: first verapamil 80 mg three times a day orally for 8 days, intermittent 5 days, and then nifedipine 10 mg orally 3 times a day for 8 days, or reverse order of application, are single-blind method Administration. During the test intake of sodium potassium content of fixed desire