目的:研究含透明质酸及白藜芦醇的护肤品对面部剥脱性点阵激光术后修复的有效性和安全性.方法:四家中心共入选100例进行面部铒/CO2点阵激光治疗的女性受试者,采用随机、安慰剂对照的方法,观察含透明质酸及白藜芦醇的贝德玛舒缓修复霜(Cicabio霜)对于剥脱性点阵激光术后28d内的修复情况.于激光术前、术后0.5h、3d、7d、28d分别进行皮肤测试.每次测试包括皮肤红斑/黑素指数和经皮水分丢失(TEWL)测量,采集面部图片,记录脱痂时间,研究者主观评价皮肤红斑、水肿情况及各种皮肤不良反应.受试者进行主观症状评分.结果:贝德玛舒缓修复霜与乳膏基质1号相比,在第3天与28天,红斑指数的改善更明显,差异具有统计学意义(P<0.05);在第7天和第28天黑素指数的改善程度均优于乳膏基质(P<0.05);在第3天和第7天术后水肿程度均轻于乳膏基质1号(P<0.05).使用贝德玛舒缓修复霜的受试者主观评价术后瘙痒、灼热、疼痛、发干等症状相对乳膏基质1号更轻微,不良反应包括皮肤刺激反应发生率也低于乳膏基质1号(P0.05).结论:贝德玛舒缓修复霜在剥脱性点阵激光术后立即使用没有明显不良反应,相对乳膏基质1号它可以更好地抑制皮肤炎症反应和后续的炎症后色素沉着.“,”Objective To evaluate the efficacy and safety of the cicabio cream, which rich in hyaluronic acid and resveratrol ,in repairing skin after ablative fractional laser. Methods A randomized controlled, placebo parallel controlled, four- center clinical trial was conducted. 100 female subjects treated with Er/ CO2 fractional laser were recruited. Skin physiological parameters were tested before laser treatment and 0.5 hour, 3 days, 7 days, 28 days after the treatment, which includes melanin and erythema indexes, transepidermal water loss (TEWL). Digital photos were taken on each visit. The degree of erythema, edema and time for decrustation were documented. The skin tolerance and adverse effect were also collected. Results Compared with control cream, the cicabio cream improved erythema better after 7 days and 28 days (P<0.05). The melanin index improved better 7 days and 28 days after applying cicabio cream (P<0.05). The degree of edema was lower in cicabio cream group 3 days and 7days compared with control cream (P<0.05). The subjective assessments of uncomfortable feeling such as itching, pain, burning and dry were milder in cicabio cream group. The cicabio cream group had less adverse events such as skin irritation (P<0.05). Conclusion the cicabio cream could effectively alleviate inflammation such as edema and erythema and reduce post-inflammatory hyperpigmentation after fractional laser. There were less adverse events in cicabio cream group.