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目的探讨肝细胞生长因子(HGF)、降钙素基因相关肽(CGRP)与小儿腹股沟斜疝的关系。方法采用ELISA法测定58例不同年龄组男性腹股沟斜疝患儿和22例正常对照组男性小儿血清HGF、CGRP浓度。结果小儿腹股沟斜疝患者血清HGF、CGRP浓度均低于正常对照组(P<0.05),其中年龄<1岁组血清HGF、CGRP水平最低(P<0.05),1岁≤年龄<3岁组和3岁≤年龄≤6岁组血清HGF、CGRP水平无显著差异(P>0.05)。结论 HGF、CGRP参与小儿腹股沟斜疝发病过程且二者浓度与年龄分布有关。
Objective To investigate the relationship between hepatocyte growth factor (HGF) and calcitonin gene related peptide (CGRP) in children with inguinal hernia. Methods Serum levels of HGF and CGRP were measured by ELISA in 58 cases of male inguinal hernia and 22 cases of normal control. Results The levels of HGF and CGRP in children with inguinal hernia were lower than those in normal control group (P <0.05). The serum HGF and CGRP levels were significantly lower in children younger than 1 year (P <0.05) Serum levels of HGF and CGRP were not significantly different between 3 years old and ≤ 6 years old (P> 0.05). Conclusions HGF and CGRP are involved in the pathogenesis of inguinal hernia in children, and their concentration is related to age distribution.