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目的探讨血清总唾液酸（ＴＳＡ）和脂质结合唾液酸（ＬＳＡ）检测对头颈部肿瘤的诊断意义及两种检测方法的优劣。②方法对１０４份血清（其中正常对照组４１份，良性肿瘤组３２份，恶性肿瘤组３１份）进行了血清ＴＳＡ与ＬＳＡ的检测。③结果恶性肿瘤组病人血清ＴＳＡ及ＬＳＡ含量均明显高于正常对照组和良性肿瘤组（ｑ＝７．８９～１０．８５，Ｐ＜０．０１）；恶性肿瘤晚期病人血清ＴＳＡ水平明显高于早期（ｔ＝２．０７，Ｐ＜０．０５），而血清ＬＳＡ水平差异无显著意义（ｔ＝１．９６，Ｐ＞０．０５）。血清ＬＳＡ对头颈部恶性肿瘤检测的敏感性明显优于ＴＳＡ（χ２＝４．５，Ｐ＜０．０５）。④结论血清ＴＳＡ及ＬＳＡ测定对头颈部恶性肿瘤的早期诊断和良恶性肿瘤的鉴别诊断均有较大临床意义。
Objective To investigate the significance of serum total sialic acid (TSA) and lipid-associated sialic acid (LSA) in the diagnosis of head and neck cancer and the advantages and disadvantages of the two methods. 2 Methods Serum TSA and LSA were detected in 104 serum samples (41 in the normal control group, 32 in the benign tumor group and 31 in the malignant tumor group). 3 Results The levels of serum TSA and LSA in the malignant tumor group were significantly higher than those in the normal control group and the benign tumor group (q=7.89 to 10.85, P<0.01). The serum TSA level was significantly higher in patients with advanced malignant tumors. In the early stage (t=2.07, P<0.05), there was no significant difference in serum LSA levels (t=1.96, P>0.05). The sensitivity of serum LSA to the detection of head and neck malignancy was significantly better than that of TSA (χ2=4.5, P<0.05). 4 Conclusions Serum TSA and LSA assays have great clinical significance for the early diagnosis of head and neck malignancy and the differential diagnosis of benign and malignant tumors.