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业已证明,胞壁酰二肽(MDP、N-乙酰胞壁酰-L-丙氨酰-D异谷氨酰胺)能增强特异性免疫反应和抗细菌及寄生虫感染的非特异性抵抗力。本文选择16种与MDP有关的化合物,其中有些是在肽链C端带有亲脂肪性分子的MDP衍化物,有的是不含N-乙酰
It has been demonstrated that muramyl dipeptide (MDP, N-acetylmuramoyl-L-alanyl-D isoglutamine) enhances specific immune responses and nonspecific resistance to bacterial and parasitic infections. In this paper, 16 kinds of MDP-related compounds were selected, some of them were MDP derivatives with lipophilic molecules at the C-terminal of the peptide chain, some of which were free of N-acetyl