论文部分内容阅读
目的:探讨养阴活血法对糖尿病GK大鼠氧化应激和硝化应激损伤的影响。方法:建立由高脂饲料喂养的糖尿病大血管并发症大鼠模型。实验分6组,正常组,模型组,参芪复方低、中、高剂量组,西药二甲双胍组。分别于灌胃第4、8、12、16周后处死各组大鼠,观察大鼠一般情况,检测空腹血糖、血清OX-LDL、3-NT水平、胸主动脉匀浆MDA、GSH-PX、SOD水平。结果和结论:具有益气养阴活血功效的参芪复方可有效而平稳地降低空腹血糖;降低OX-LDL、3-NT、MDA水平;升高GSH-PX、SOD水平。
Objective: To investigate the effects of nourishing Yin and activating blood on oxidative stress and nitrification stress in diabetic GK rats. Methods: To establish a rat model of diabetic macroangiopathy fed with high fat diet. The experiment was divided into 6 groups, normal group, model group, Shenqi compound low, medium and high dose group, western medicine metformin group. Rats in each group were sacrificed at 4, 8, 12 and 16 weeks after gavage respectively. The general conditions of rats were observed. The levels of fasting blood glucose, serum OX-LDL and 3-NT, MDA in the thoracic aorta, GSH-PX , SOD level. RESULTS AND CONCLUSIONS: Shenqi Compound, which has the effect of nourishing yin and activating blood circulation, can effectively and smoothly reduce fasting blood glucose, reduce the levels of OX-LDL, 3-NT and MDA, and increase the levels of GSH-PX and SOD.