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目的研究慢性肾衰竭(CRF)患者炎性因子超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)与心脏功能指标心指数(CI)、射血分数(EF)、心室舒张末期容积(VEDV)改变的关系。观察肾功损害的程度与炎性因子升高的水平是否相关。方法本试验选择2007年1月至2008年6月住院的45例慢性肾功衰竭患者作为试验组,24位健康志愿者作为对照组。分别检验hs-CRP水平,IL-6水平及肾功水平。所有患者检查心脏功能,并将资料进行统计学处理。结果①CRF患者血清中hs-CRP、IL-6的平均水平明显高于对照组(P<0.01);②根据hs-CRP水平分组后发现,hs-CRP>4mg/L组的心脏功能各项指标与hs-CRP<4mg/L组相比,差异有显著性意义(P<0.01)。结论慢性肾衰竭患者随着肾功改变的加重,炎性因子的水平呈增高趋势。炎性因子水平的升高,对心脏泵血功能指标CI、EF、VEDV也有一定影响。
Objective To investigate the expression of hs-CRP, IL-6 and cardiac function index (CI), ejection fraction (EF), blood pressure and blood pressure in patients with chronic renal failure Ventricular end diastolic volume (VEDV) changes in the relationship. To observe whether the degree of renal damage is related to the level of inflammatory cytokines. Methods This study selected 45 patients with chronic renal failure who were hospitalized from January 2007 to June 2008 as experimental group and 24 healthy volunteers as control group. The levels of hs-CRP, IL-6 and renal function were tested respectively. All patients examined cardiac function, and the data were statistically analyzed. Results ① The mean levels of hs-CRP and IL-6 in CRF patients were significantly higher than those in control group (P <0.01). ② According to the hs-CRP level, the indexes of cardiac function in hs-CRP> 4mg / Compared with hs-CRP <4mg / L group, the difference was significant (P <0.01). Conclusion With the aggravation of renal function, the levels of inflammatory cytokines in chronic renal failure patients tend to increase. Inflammatory factor levels increased, the heart pump blood function indicators CI, EF, VEDV also have a certain impact.