目的　探讨环境刺激对缺氧缺血性脑损伤 (hypoxic ischemicbraindamage,HIBD)新生大鼠脑功能的影响。方法　选用 7日龄雄性SD大鼠 5 1只 ,其中 36只通过结扎右侧颈总动脉 ,吸入氧体积浓度为 (8 0± 0 5 ) %的氮氧混合气体 ,制作新生大鼠HIBD模型 ,制模后的大鼠分为干预组和非干预组 ;正常对照组大鼠 15只 (假手术动物 )。采用早期触摸 (neonatalhandling)和丰富环境 (enrichedenvironment)刺激进行干预 ,干预时间为 30d ,干预结束后进行感觉运动功能 (悬吊试验、行走试验 )和行为检测 (三等分迷宫试验 )以判断干预效果。结果　非干预组大鼠分辨学习能力较干预组和正常对照组差 (P <0 0 1) ,达到学会标准所需的训练次数分别为 :非干预组 (4 5± 9)次、干预组 (2 7± 5 )次、正常对照组 (2 4± 8)次 ;非干预组大鼠感觉运动功能低于干预组和正常对照组 (P <0 0 1) ,悬吊试验时间分别为非干预组 (15± 3)s、干预组 (2 2± 4)s、正常对照组 (36± 6 )s;行走试验时间分别为 (7 0± 1 1)s、(4 0± 0 8)s、(4 0± 0 5 )s;干预组和非干预组大鼠大脑皮层死亡细胞百分数分别为 (35 7± 8 9) %和 (39 1± 10 9) % ,海马部位分别为 (38 5± 6 3) %和 (39 3± 10 4) % ,干预组与非干预组脑损伤程度差异无显 Objective To investigate the effects of environmental stimuli on brain function in neonatal rats with hypoxic ischemic brain injury (HIBD). Methods Fifty-one male Sprague-Dawley rats were used in this study. Thirty-six male HIBD models were established by ligation of the right common carotid artery and inhalation of a mixture of nitrogen and oxygen with an oxygen concentration of (80 ± 0.5)%. The model rats were divided into intervention group and non-intervention group; 15 rats in normal control group (sham-operated animals). Interventions were performed using neonatal handling and enrichedenvironment stimulation for 30 days. After the intervention, sensory motor function (suspension test, walking test) and behavior test (trisection maze test) were performed to judge the intervention effect . Results Compared with the intervention group and the normal control group, the discrimination learning ability of the non-intervention group was significantly lower than that of the intervention group and the normal control group (P <0.01). The number of training required to reach the standard was: non-intervention group (45 ± 9) 2 7 ± 5) times and normal control group (24 ± 8) times. The sensory motor function of the non-intervention group was lower than that of the intervention group and the normal control group (P <0.01), and the suspension test time was non-intervention (15 ± 3) s, intervention group (22 ± 4) s, and normal control group (36 ± 6) s respectively. The walking test time was (70 ± 1 1) s and (40 ± 8)% and (39 1 ± 10 9)% in hippocampus and (38 ± 5) s in hippocampus, respectively ± 6 3)% and (39 3 ± 10 4)%, respectively. There was no significant difference in the degree of brain injury between intervention group and non-intervention group