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目的 探讨恶性淋巴瘤患者医院细菌感染的发生率、易患因素及抗生素疗效分析。方法 对我科近 3年收治的恶性淋巴瘤患者细菌感染及抗生素使用进行统计分析。结果 2 4 2例恶性淋巴瘤患者中并发细菌感染者 60例 (占 2 4 .8% )。感染部位以下呼吸道多见。病原菌以革兰阴性菌为主。易患因素为老年、病理组织分型属中高度恶性、临床 ～ 期和粒细胞缺乏症。抗生素的临床疗效与药敏检测结果基本相符。革兰阴性菌以依米配能 /西司他丁 (泰能 )、丁胺卡那和环丙沙星疗效较好 ,革兰阳性菌以泰能、头孢呋辛和万古霉素疗效较好。结论 恶性淋巴瘤患者免疫力低下 ,医院细菌感染率较高。对重度感染的患者应尽早使用高效广谱抗生素治疗。
Objective To investigate the incidence, susceptible factors and antibiotic efficacy of nosocomial bacterial infections in patients with malignant lymphoma. Methods The bacterial infections and antibiotic use in patients with malignant lymphoma treated in our hospital for nearly 3 years were statistically analyzed. Results Among 242 cases of malignant lymphoma, 60 cases were complicated with bacterial infection (24.4%). Respiratory tract infection more common. Gram-negative bacteria mainly bacteria. Risk factors for the elderly, pathological tissue type is a highly malignant, clinical stage and agranulocytosis. The clinical efficacy of antibiotics and drug sensitivity test results are basically consistent. Gram-negative bacteria in accordance with the mipin / cilastatin (Thailand to), amikacin and ciprofloxacin better efficacy, Gram-positive bacteria to Thailand, cefuroxime and vancomycin better effect . Conclusion The immunity of patients with malignant lymphoma is low, and the bacterial infection rate in hospital is high. Patients with severe infections should be treated with high-efficiency broad-spectrum antibiotics as soon as possible.