论文部分内容阅读
辅助生殖技术(ART)目前成为了人们解决不孕不育的主要方式,但是通过ART出生的后代发生基因印迹改变导致表观遗传学疾病的报道出现,使得辅助生殖技术的安全性受到了人们的关注。早期胚胎发育受印迹基因的调控,而Igf2/H19基因是最早被发现的内源性印迹基因,正确的印迹对哺乳动物的胎儿和胎盘正常发育至关重要。Igf2/H19基因编码重要的印迹基因,控制正常的早期胚胎发育。Igf2/H19基因与ART早期胚胎的关系尚不十分明确,有待进一步的深入研究和探讨。
Artificial Reproductive Technology (ART) is now the mainstay of infertility treatment in humans. However, the genetic imprinting of ART-born offspring has led to reports of epigenetic diseases that make the safety of assisted reproductive technology affected by people’s attention. Early embryonic development is regulated by imprinted genes, while Igf2 / H19 is the earliest discovered endogenous imprinted gene. Correct imprinting is crucial for normal fetal and placental development in mammals. The Igf2 / H19 gene encodes important imprinted genes and controls normal early embryonic development. The relationship between Igf2 / H19 gene and ART early embryos is not yet clear enough to be further studied and discussed.