Background: Markov chains (MC) have been widely used to model molecular sequences.The estimations of MC transition matrix and confidence intervals of the transi
Bisulfite sequencing (BS-seq) technology measures DNA methylation at single nucleotide resolution.A key task in BS-seq data analysis is to identify differential
Background:Statistical validation of predicted complexes is a fundamental issue in proteomics and bioinformatics.The target is to measure the statistical signif