论文部分内容阅读
目的 :探讨鼻腔局部特异性脱敏 ( LNIT)的疗效和免疫机理。方法 :用 LNIT治疗常年性变应性鼻炎 ( PAR)患者 1 42例 ,并对其中的 30例进行免疫学观察。结果 :LNIT与传统的皮下免疫疗法的疗效相似 ( P >0 .0 5)。免疫观察表明 ,治疗后患者鼻分泌物中的 Ig A显著增加 ( P <0 .0 5) ;鼻分泌物总 Ig E、血清总 Ig E和螨、豚草的特异性 Ig E水平都有所下降 ,但仍无显著差异( P >0 .0 5)。结论 :LNIT确能通过增强局部免疫功能 ,使 PAR的治疗获得较好的效果。
Objective: To investigate the efficacy and immunological mechanism of nasal localized desensitization (LNIT). Methods: One hundred and forty-two patients with perennial allergic rhinitis (PAR) were treated with LNIT, and 30 of them were immunologically observed. Results: LNIT was similar to traditional subcutaneous immunotherapy (P> 0.05). Immune observations showed that IgA in nasal secretions was significantly increased (P <0.05) in patients with nasal secretions after treatment; total IgE in nasal secretions, total serum IgE and mite, and specific IgE levels in ragweed Decreased, but still no significant difference (P> 0.05). CONCLUSION: LNIT did improve PAR therapy by enhancing local immune function.