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研究马钱子碱对心肌电生理方面的影响。采用常规微电极技术同步记录收缩力的方法，观察了马钱子碱对豚鼠心脏乳头肌动作电位（Ａｐ）及收缩力（Ｆｃ）的影响。实验结果表明：马钱子碱在浓度大于等于１×１０－６ｍｏｌ·Ｌ－１时，浓度依赖地延长快反应动作电位（ＦＡＰ）及高钾除极组织胺和氯化钡诱发的慢反应动作电位ＳＡＰ的ＡＰＤ５０、ＡＰＤ９０，在浓度大于等于３×１０－６ｍｏｌ·Ｌ－１时，抑制ＦＡＰ及ＳＡＰ的Ｆｃ，在浓度大于等于１×１０－５ｍｏｌ·Ｌ－１时，还可抑制ＦＡＰ及ＳＡＰ的ＡＰＡ、Ｖｍａｘ。提示马钱子碱具有阻断心肌Ｋ＋、Ｎａ＋、Ｃａ２＋通道的作用。
Studied the effect of strychnine on myocardial electrophysiology. The effect of strychnine on the action potential (Ap) and contractility (Fc) of guinea pig papillary muscles was observed using the conventional microelectrode technique for simultaneous recording of contractile force. The experimental results show that when the concentration of strychnine is greater than or equal to 1×10-6 mol·L-1, concentration-dependently prolonging the fast response action potential (FAP) and the slow response induced by high potassium depolarizing histamine and strontium chloride The potential APD50 and APD90 of SAP inhibited the Fc of FAP and SAP when the concentration was greater than or equal to 3×10-6 mol·L-1. When the concentration was greater than or equal to 1×10-5 mol·L-1, it could also inhibit FAP and SAP. APA, Vmax. It suggests that strychnine has the effect of blocking the myocardial K+, Na+, Ca2+ channels.