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目的观察氯吡格雷联合阿司匹林治疗急性冠脉综合征的临床疗效和安全性。方法 184例急性冠脉综合征患者随机分为治疗组和对照组,2组均给予常规内科治疗,在此基础上,治疗组加用氯吡格雷首剂300mg,随后75mg,每日1次,口服;阿司匹林0.3g,每日1次,口服,连用3d后,改为0.1g,每日1次,口服。半年为1个疗程。观察2组临床疗效及治疗后半年的心脏事件发生情况。结果治疗组总有效率为95.45%,对照组75.00%,2组比较差异有统计学意义(P<0.05)。治疗组发生急性心肌梗死4例(4.5%),对照组发生24例(25.00%)。治疗组心电图及肌钙蛋白水平均较对照组有明显改善(P均<0.05)。结论氯吡格雷联合阿司匹林治疗急性冠脉综合征安全有效。
Objective To observe the clinical efficacy and safety of clopidogrel combined with aspirin in the treatment of acute coronary syndrome. Methods A total of 184 patients with acute coronary syndrome were randomly divided into treatment group and control group. Both groups were given conventional medical treatment. On the basis of this, the treatment group was given clopidogrel first dose 300mg, then 75mg once daily, Oral; aspirin 0.3g, 1 day, orally, once every 3d, changed to 0.1g, 1 times daily, orally. Six months for a course of treatment. The clinical efficacy and the incidence of cardiac events in the second half of the treatment were observed. Results The total effective rate was 95.45% in the treatment group and 75.00% in the control group. There was significant difference between the two groups (P <0.05). In the treatment group, 4 cases (4.5%) had acute myocardial infarction and 24 cases (25.00%) in the control group. Electrocardiogram and troponin levels in the treatment group were significantly improved compared with the control group (all P <0.05). Conclusion Clopidogrel combined with aspirin in the treatment of acute coronary syndrome is safe and effective.