论文部分内容阅读
[目的]观察宫颈癌根治术联合放、化疗治疗Ⅰa~Ⅱa期宫颈鳞癌患者的临床疗效,并与单纯根治手术疗效进行比较。[方法]采用回顾性分析方法,将2007年1月至2012年7月期间收治的经根治手术治疗并具有复发、转移高危因素的94例Ⅰa~Ⅱa期宫颈鳞癌患者的临床相关资料进行整理、分析,其中63例患者宫颈癌根治术后3~5个月内行盆腔外放疗加TP方案全身化疗2~4周期;另外31例患者仅行单纯宫颈癌根治手术治疗,对两组患者的临床疗效进行比较分析。[结果]随访时间为12~79个月,中位随访37个月,随访期内,手术联合放、化疗组与单纯手术组的盆腔或阴道残端局部复发率分别为3.17%和61.29%,远处脏器或组织转移率分别为17.46%和51.61%,差异均有显著统计学意义(P<0.05)。[结论]对于Ⅰa~Ⅱa期宫颈鳞癌根治性手术后具有复发、转移高危因素的患者,术后联合放、化疗能明显降低其局部复发率及远处转移率,具有较高的临床应用价值。
[Objective] To observe the curative effect of cervical cancer combined with radical radiotherapy and chemotherapy in the treatment of stage Ⅰa-Ⅱa cervical squamous cell carcinoma, and compare the curative effect with radical radical operation. [Methods] The clinical data of 94 patients with stage Ⅰa-Ⅱa cervical squamous cell carcinoma who underwent radical operation and who had the risk of relapse and metastasis who were treated from January 2007 to July 2012 were retrospectively analyzed. , Of which 63 cases of cervical cancer within 3 to 5 months after radical operation with pelvic radiotherapy plus TP regimen 2 to 4 cycles of chemotherapy; the other 31 patients underwent radical surgery alone cervical cancer, the two groups of patients with clinical Comparative efficacy analysis. [Results] The follow-up time ranged from 12 to 79 months, with a median follow-up of 37 months. The local recurrence rates of pelvic or vaginal stump in the surgery combined radiotherapy and chemotherapy group and the surgery alone group were 3.17% and 61.29%, respectively, The distant organ or tissue metastasis rates were 17.46% and 51.61%, respectively, with significant differences (P <0.05). [Conclusion] For patients with stage Ⅰa-Ⅱa cervical squamous cell carcinoma who have the recurrence and metastasis after radical surgery, combined with radiotherapy and chemotherapy can significantly reduce the local recurrence rate and distant metastasis rate, which has a high clinical value .