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目的观察还原型谷胱甘肽注射液配合泼尼松、环磷酰胺治疗难治性肾病综合征的疗效。方法将60例难治性肾病综合征患者随机分为2组各30例,均给予泼尼松、环磷酰胺及常规对症治疗,治疗组在此基础加用还原型谷胱甘肽,观察2组治疗前后的临床表现、24h尿蛋白定量、血白蛋白、血尿素氮、血肌酐、血总胆固醇情况。结果治疗组总有效率(96.67%)高于对照组(76.67%);治疗后治疗组和对照组各项生化指标与治疗前比较明显改善(P<0.01或P<0.05),治疗后治疗组生化指标改善比对照组更明显(P<0.05)。结论还原型谷胱甘肽配合泼尼松、环磷酰胺治疗难治性肾病综合征疗效肯定。
Objective To observe the effect of reduced glutathione injection combined with prednisone and cyclophosphamide in the treatment of refractory nephrotic syndrome. Methods Sixty patients with refractory nephrotic syndrome were randomly divided into two groups of 30 patients. All patients were given prednisone, cyclophosphamide and conventional symptomatic treatment. The treatment group was treated with reduced glutathione, and the observation group 2 Group before and after treatment of clinical manifestations, 24h urinary protein, serum albumin, blood urea nitrogen, serum creatinine, blood total cholesterol. Results The total effective rate (96.67%) in the treatment group was significantly higher than that in the control group (76.67%). After treatment, the biochemical indexes of the treatment group and the control group were significantly improved (P <0.01 or P <0.05) Biochemical indicators improved more significantly than the control group (P <0.05). Conclusion Reduced glutathione with prednisone, cyclophosphamide in the treatment of refractory nephrotic syndrome is sure.