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目的:探讨慢性心力衰竭(CHF)患者血清胎盘生长因子(Pl GF)和高敏C-反应蛋白(hs-CRP)的变化及临床意义。方法:选取正常对照组60例和CHF患者170例,后者又分缺血性心脏病组和非缺血性心脏病组。测定血清Pl GF和hs-CRP水平,比较各组间的差异,分析Pl GF和hs-CRP之间的相关性。结果:CHF组血清Pl GF、hs-CRP水平显著高于对照组(P<0.01);且随着NYHA心功能分级加重而逐级升高。血清Pl GF水平缺血性心脏病组较非缺血性心脏病组显著升高(P<0.05)。相关性分析显示:Pl GF与hs-CRP呈正相关,具有统计学意义(r=0.543;P<0.01)。结论:血清Pl GF与hs-CRP可能参与CHF患者的病情发展过程。
Objective: To investigate the changes and clinical significance of serum placental growth factor (PlGF) and high-sensitivity C-reactive protein (hs-CRP) in patients with chronic heart failure (CHF). Methods: Sixty normal controls and 170 CHF patients were selected, which were divided into ischemic heart disease group and non-ischemic heart disease group. The serum levels of Pl GF and hs-CRP were measured. The differences between groups were compared, and the correlation between Pl GF and hs-CRP was analyzed. Results: The levels of Pl GF and hs-CRP in CHF group were significantly higher than those in control group (P <0.01), and were gradually increased with the increase of NYHA functional class. Serum Pl-GF levels in ischemic heart disease were significantly higher than those in non-ischemic heart disease (P <0.05). Correlation analysis showed that: Pl GF was positively correlated with hs-CRP, with statistical significance (r = 0.543; P <0.01). Conclusion: Serum Pl GF and hs-CRP may be involved in the progression of CHF.