论文部分内容阅读
目的观察灯盏花素对慢性阻塞性肺疾病急性加重期患者(AECOPD)的肺功能和血液流变学的影响。方法将200例AECOPD患者随机分为观察组和对照组各100例。对照组给予常规治疗,观察组在常规治疗的基础上给予灯盏花素治疗。对比观察2组治疗前后1秒钟用力呼气容积与用力肺活量比值(FEV1/FVC),FEV1,FVC,高峰呼气流速(PEF)水平,氧分压(Pa O2)、二氧化碳分压(Pa CO2)水平。对比观察2组治疗前后全血黏度、红细胞计数、红细胞比容。结果治疗后2组FEV1/FVC、FEV1、FVC、PEF、Pa O2水平均升高,Pa CO2水平均降低,且观察组优于对照组;治疗后观察组全血黏度、红细胞计数和红细胞比容均低于治疗前及对照组,差异均有统计学意义(P<0.05)。对照组治疗后全血黏度、红细胞计数及红细胞比容均低于治疗前,但差异无统计学意义(P>0.05)。结论灯盏花素治疗AECOPD可明显改善患者的肺功能,降低血液黏稠度,纠正高凝状态,改善微循环,增加血氧饱和度,改善肺功能,值得临床推广应用。
Objective To observe the effect of breviscapine on pulmonary function and hemorheology in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods 200 patients with AECOPD were randomly divided into observation group and control group of 100 cases. The control group was given routine treatment, and the observation group was given breviscapine treatment on the basis of routine treatment. The FEV1 / FVC, FEV1, FVC, peak expiratory flow (PEF), Pa O2 and Pa CO2 were observed and compared between the two groups before and after treatment )Level. Comparison of two groups before and after treatment of whole blood viscosity, red blood cell count, hematocrit. Results After treatment, the levels of FEV1 / FVC, FEV1, FVC, PEF and Pa O2 in both groups were increased and PaCO2 levels were lower in the observation group than in the control group. After treatment, the whole blood viscosity, erythrocyte count and hematocrit Were lower than before treatment and control group, the difference was statistically significant (P <0.05). The whole blood viscosity, red blood cell count and hematocrit of the control group after treatment were lower than before treatment, but the difference was not statistically significant (P> 0.05). Conclusion Breviscapine treatment of AECOPD can significantly improve the patient’s lung function, reduce blood viscosity, correct hypercoagulable state, improve microcirculation, increase oxygen saturation, improve lung function, worthy of clinical application.