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[目的]研究乳腺癌分子分型与术后复发转移的关系。[方法]收集术后复发转移的乳腺癌患者的临床病理资料,明确患者复发转移的部位及时间,分析各分子亚型与临床病理特征以及复发转移部位、时间的关系。[结果]入组299例术后复发转移的乳腺癌患者,其中Luminal A型、Luminal B型、Her-2阳性型和Basal-like型分别为92例、79例、47例和81例。各分子亚型中年龄(P=0.034)、月经状况(P=0.013)、肿瘤组织学分级(P=0.000)、术后淋巴结转移情况(P=0.035)、术后复发转移时间(P=0.000)以及术后复发转移部位(P=0.007)存在显著差异。Cox逐步回归分析显示,组织学分级(P=0.000)和分子分型(P=0.000)是乳腺癌术后复发转移的独立预后因子。[结论]乳腺癌分子分型作为传统TNM分期的重要补充,能够很好地预测乳腺癌术后复发转移部位和时间,有助于临床医师对术后患者进行个体化随访筛查。
[Objective] To study the relationship between breast cancer molecular typing and postoperative recurrence and metastasis. [Methods] The clinicopathological data of patients with recurrent and metastatic breast cancer were collected. The site and time of recurrence and metastasis were determined. The relationship between the molecular subtypes and clinicopathological characteristics, recurrence and metastasis location and time were analyzed. [Results] A total of 299 patients with breast cancer with recurrence and metastasis were enrolled. Among them, 92 patients were Luminal A, Luminal B, Her-2 and Basal-like, 79, 47 and 81 respectively. (P = 0.013), tumor histological grade (P = 0.000), postoperative lymph node metastasis (P = 0.035), postoperative recurrence and metastasis time (P = 0.000) ) And postoperative recurrence and metastasis (P = 0.007) there are significant differences. Cox stepwise regression analysis showed that histological grade (P = 0.000) and molecular typing (P = 0.000) were independent prognostic factors for postoperative recurrence and metastasis of breast cancer. [Conclusion] Molecular typing of breast cancer, as an important complement to the traditional TNM staging, can well predict the recurrence and metastasis location and time of postoperative breast cancer and help clinicians to conduct personalized follow-up screening of postoperative patients.