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目的研究拉西地平治疗轻中度原发性高血压临床疗效。方法以我院70例轻中度原发性高血压患者为研究对象,所有入组患者每日早饭后服药4 mg,每周进行至少一次的随访,随访内容包括询问症状、服药情况、治疗反应。通过随访观察患者治疗前后血压、心率和生化指标变化,直至疗程结束。结果拉西地平治疗6周后,平均坐位血压由治疗前171.0/101.7 mm Hg降至144.1/85.9 mmHg,总有效率87.1%,差异均有统计学意义(P<0.01),治疗前后生化指标及心率无明显改变,差异无统计学意义(P>0.05)。常见不良反应为头痛、头晕、面红、心悸,但反应轻、持续时间短。结论拉西地平减压作用确切,安全有效,对于治疗轻中度原发性高血压有良好的疗效,值得临床推广。
Objective To study the clinical efficacy of lacidipine in the treatment of mild to moderate essential hypertension. Methods 70 patients with mild to moderate essential hypertension in our hospital were enrolled in this study. All patients were given 4 mg daily after breakfast and at least one weekly visit. The follow-up included inquiring about symptom, medication taking, response to treatment . Follow-up observation of patients before and after treatment of blood pressure, heart rate and biochemical changes, until the end of treatment. Results After 6 weeks of lacidipine treatment, mean sitting blood pressure decreased from 171.0 / 101.7 mm Hg before treatment to 144.1 / 85.9 mmHg, with a total effective rate of 87.1% (all P <0.01). Before and after treatment, No significant change in heart rate, the difference was not statistically significant (P> 0.05). Common adverse reactions are headache, dizziness, redness, heart palpitations, but the reaction light, short duration. Conclusion The effect of lacidipine on decompression is definite, safe and effective. It has good curative effect for the treatment of mild to moderate essential hypertension and is worthy of clinical promotion.