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目的 研究胃癌组织转化生长因子 β1(TGF -β1)表达和意义及与癌细胞增殖活性的关系。 方法 运用免疫组化S -P法检测 5 0例胃癌、10例正常胃黏膜TGF -β1与Ki -67抗原的表达。 结果 胃癌TGF -β1表达率与Ki67-LI值明显高于正常胃黏膜。TGF -β1表达与分化程度、淋巴结转移和浸润深度显著相关。淋巴结转移组Ki67-LI值明显高于无淋巴结转移组 ,不同浸润深度的Ki67-LI值差异有显著性。胃癌TGF -β1阳性表达组Ki67-LI值明显高于TGF -β1阴性表达组。 结论 TGF -β1过表达胃癌组织细胞具有较强的增殖活性 ,TGF -β1不能抑制癌细胞增殖。TGF -β1促进胃癌细胞浸润转移。TGF -β1和Ki -67可作为评估胃癌生物学行为的参考指标
Objective To study the expression and significance of transforming growth factor-β1 (TGF-β1) in gastric carcinoma and its relationship with the proliferation of cancer cells. Methods The expressions of TGF-β1 and Ki-67 in 50 cases of gastric cancer and 10 cases of normal gastric mucosa were detected by immunohistochemical S-P method. Results The expression of TGF-β1 and Ki67-LI in gastric cancer were significantly higher than those in normal gastric mucosa. TGF-β1 expression and differentiation, lymph node metastasis and depth of invasion were significantly correlated. The Ki67-LI value in lymph node metastasis group was significantly higher than that in non-lymph node metastasis group, and Ki67-LI value in different depth of invasion was significantly different. The Ki67-LI value of TGF-β1 -positive expression in gastric cancer was significantly higher than that in TGF-β1-negative expression. Conclusion TGF-β1 overexpression in gastric cancer cells has a strong proliferative activity, TGF-β1 can not inhibit cancer cell proliferation. TGF-β1 promotes gastric cancer cell invasion and metastasis. TGF-β1 and Ki-67 can be used as a reference to evaluate the biological behavior of gastric cancer