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目的探讨喘息儿童肺炎支原体(MP)感染的病原学流行特点,进一步为临床诊治MP感染喘息儿童提供依据。方法采用间接免疫荧光法检测4806例喘息患儿血清中MP-免疫球蛋白M(IgM)抗体,根据年龄[幼儿组(<1岁)1806例、婴儿组(1~3岁)2389例、学龄前组(3~6岁)498例及学龄组(6~14岁)113例]和季节[春季组(3~5月)808例、夏季组(6~8月)135例、秋季组(9~11月)1013例、冬季组(12~2月)2850例]的MP阳性率情况进行统计分析。结果 4806例喘息患儿MP-IgM抗体阳性1443例,总阳性率30.02%;各年龄组MP-IgM抗体阳性率以幼儿组的(38.55%)最高,差异有统计学意义(P<0.01),学龄组的(13.27%)最低,差异有统计学意义(P<0.05);秋季组(32.28%)、春季组(31.06%)、冬季组(29.65%)的感染阳性率高于夏季组(14.81%),差异有统计学意义(P<0.01)。结论喘息儿童MP感染有人群性和季节性流行特点,幼儿为易感人群,秋季、春季、冬季为高发季节。
Objective To investigate the etiological characteristics of mycoplasma pneumoniae (MP) infection in wheezing children and to provide evidence for clinical diagnosis and treatment of wheezing in children with MP infection. Methods The serum immunoglobulin M (IgM) antibodies in 4806 cases of asthmatic children were detected by indirect immunofluorescence. According to age, there were 1, 886 infants (<1 year old), 2389 infants (1 ~ 3 years old) 498 cases of former group (3-6 years old) and 113 cases of school-age group (6-14 years old) and 808 cases of season [March-May], 135 cases of summer group (June-August) 913 months) 1013 cases, winter group (12 ~ February) 2850 cases of MP positive rate of statistical analysis. Results The positive rate of MP-IgM antibody in 4806 asthmatic children was 1443 (30.02%). The positive rate of MP-IgM antibody in each age group was the highest (38.55%), the difference was statistically significant (P <0.01) The positive rate of infection in autumn group (32.28%), spring group (31.06%) and winter group (29.65%) was the highest (P <0.05) %), The difference was statistically significant (P <0.01). Conclusion The prevalence of MP infection in wheezing children is characterized by population and seasonal epidemics. Children are predisposed to the disease and fall, spring and winter are the high incidence seasons.