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本实验通过对肝纤维化大鼠甲状腺功能的观察,以探讨肝纤维化程度和甲状腺功能变化之间的联系。 材料和方法 选用雄性Wistar大鼠51只,体重180～200克,以平衡饲料喂养,随机分为四个观察组,即正常对照组,病理对照组以及中药的两个治疗组(A组和B组),每组大鼠数分别为13、13、12及13只。肝纤维化大鼠模型是通过间歇性腹腔注射二甲基亚硝胺而建立。 治疗用中药选用益气活血方即方A(由黄芪、丹参、黄精等组成)和清肝补肾方即方B(由柴胡、菟丝于、黄芩等组成)。按一定程序煎制,每毫升含3克生药。经胃灌药,每日一次,A组每日1.8ml/只,B组1.5ml/只,共治疗8周,治疗自造模开始后两周进行,病理及正常对照组则同时以2ml的蒸馏水灌胃。
This experiment through the observation of thyroid function in rats with liver fibrosis to explore the relationship between the degree of liver fibrosis and thyroid function changes. MATERIALS AND METHODS: Fifty-one male Wistar rats weighing 180 to 200 grams were fed with balanced diet and randomly divided into four observation groups: normal control group, pathological control group and traditional Chinese medicine treatment group (Group A and B Group), the number of rats in each group was 13, 13, 12 and 13 respectively. Rat models of hepatic fibrosis were established by intermittent intraperitoneal injection of dimethylnitrosamine. Treatment of traditional Chinese medicine used Yiqihuoxue Fang Fang A (from Astragalus, Salvia, Polygonatum and other components) and Qinggan Bushen Fang Fang B (from Bupleurum, reeling in, such as baicalin composition). Prepared according to a certain procedure, each containing 3 grams of crude drug. Once a day, A group of daily 1.8ml / only, B group 1.5ml / only, a total of 8 weeks treatment, since the beginning of the model two weeks after the start of the pathological and normal control group while 2ml of Distilled water gavage.