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目的:对硫普罗宁2种给药方案治疗抗结核药所致药物性肝炎进行药物经济学评价。方法:115例抗结核药所致药物性肝炎患者按治疗方案分为A、B两组。A组60例,给予硫普罗宁0.2 g,ivd qd,治疗7 d后予硫普罗宁片0.2 g,po tid治疗7 d;B组55例,给予硫普罗宁0.2 g,ivd qd,治疗14 d。观察2组疗效并进行最小成本分析。结果:A、B组总有效率分别为83.33%、85.45%(P>0.05);A、B组人均成本分别为950.6元、1 330.7元,A组治疗成本低于B组。结论:2组总有效率相当,A组方案更经济。
OBJECTIVE: To evaluate the pharmacoeconomic evaluation of two kinds of administration regimens of tiopronin in the treatment of drug-induced hepatitis caused by antituberculosis drugs. Methods: One hundred and fifteen patients with drug-induced hepatitis due to anti-TB drugs were divided into A and B groups according to the treatment plan. A group of 60 patients given tiopronin 0.2 g, ivd qd, 7 days after treatment with tiopronin 0.2 g, po tid treatment for 7 days; B group 55 cases, given tiopronin 0.2 g, ivd qd, treatment 14 d. Two groups were observed and the minimum cost analysis was performed. Results: The total effective rates of group A and group B were 83.33% and 85.45%, respectively (P> 0.05). The average cost of group A and group B was 950.6 yuan and 1330.7 yuan respectively. The treatment cost of group A was lower than that of group B. Conclusion: The total effective rate in the two groups is comparable, and the group A scheme is more economical.