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Objective: To detect mitochondrial DNA (mtDNA) 4977 bp deletion in the oocytes of patients with diminished ovarian reserve, and help to understand its impact on the reproductive potential.Methods: Eighty infertile patients treated with in vitro fertilization-embryo transfer (IVF-ET) from Mar to Sep 2008 in Xiangya Hospital were recruited and divided into two groups according to ovarian reserve: diminished ovarian reserve (DOR, with basal follicular stimulating hormone (bFSH) levels ≥12 U/L and/or bilateral antral follicle count (AFC)≤5 ) and normal ovarian reserve (NOR, with bFSH levels