论文部分内容阅读
目的 探讨CO2 气腹对肝硬变大鼠门脉血流量的影响。 方法 制作肝硬变大鼠模型 ,施加不同压力的气腹 ,分别测平均动脉压、门静脉压力、下腔静脉压、门静脉血流 ,计算门静脉阻力。 结果 平均动脉压、下腔静脉压在不同气腹压力下无明显变化 ,两组大鼠门静脉压力在 10mmHg时出现显著差异 ,随着压力的升高而升高。正常大鼠的门静脉血流量在 2 0mmHg下与 0mmHg下比较有显著差异 ,而肝硬变大鼠的门静脉血流量在 10mmHg下与 0mmHg下比较已有显著差异。正常大鼠门静脉阻力随着压力的升高在 10mmHg时出现显著差异 ,以后继续升高 ,肝硬化大鼠门静脉阻力随着压力的升高持续升高。 结论 CO2 气腹致肝硬化大鼠门静脉血流减少 ,且减少程度重于正常大鼠
Objective To investigate the effects of CO2 pneumoperitoneum on portal blood flow in cirrhotic rats. Methods Rat model of liver cirrhosis was established. Pneumoperitoneum with different pressures was applied. The mean arterial pressure, portal pressure, vena cava pressure and portal vein blood flow were measured and the portal vein resistance was calculated. Results The mean arterial pressure and vena cava pressure did not change significantly under different pneumoperitoneal pressure. The portal venous pressure of the two groups showed significant difference at 10mmHg, and increased with the increase of pressure. The portal vein blood flow in normal rats was significantly different from that at 0 mmHg at 20 mmHg, whereas the portal blood flow in cirrhotic rats was significantly different at 10 mmHg compared to 0 mmHg. The normal rat portal vein resistance with pressure increased at 10mmHg significantly different, and then continue to rise, portal vein resistance in cirrhotic rats with pressure continued to rise. Conclusions The portal vein blood flow in cirrhotic rats with CO2 pneumoperitoneum is decreased, and the degree of decrease is heavier than that in normal rats