目的评价前列腺特异抗原(PSA)新参数(F/T)/PSAD对血清PSA在4~10ng/ml区间的前列腺癌(PCa)的诊断价值。方法选取经直肠B超引导下前列腺多点穿刺活检血PSA测值在4~10ng/ml的88例患者,其中确诊PCa患者21例,BPH患者67例。比较分析F/T比值、PSAD、(F/T)/PSAD在设定的各阈值范围内,对PCa诊断的敏感度及特异度。结果Pca患者的(F/T)/PSAD)均值明显低于BPH患者(P<0.001)。F/T比值、PSAD、(F/T)/PSAD在设定的各阈值范围内诊断PCa的敏感度分别为66.67%,76.19%和85.71%;特异度分别为41.79%,43.28%和68.66%。(F/T)/PSAD诊断PCa的特异度有显著优势(P<0.05)。结论应用(F/T)/PSAD能有效提高PSA在4~10ng/ml区间的PCa检出率,有效减少不必要的穿刺活检。 Objective To evaluate the diagnostic value of the new parameter of prostate specific antigen (PSA) / PSAD in prostate cancer (PCa) with serum PSA ranging from 4 to 10 ng / ml. Methods Seventy eight patients undergoing transrectal B-guided prostate biopsy with blood PSA levels between 4 and 10 ng / ml were selected. Among them, 21 were diagnosed with PCa and 67 with BPH. The sensitivity and specificity of F / T ratio, PSAD, (F / T) / PSAD in the setting of each threshold were compared and analyzed. Results The mean (F / T) / PSAD of Pca patients was significantly lower than that of BPH patients (P <0.001). The sensitivities of F / T ratio, PSAD and (F / T) / PSAD in diagnosing PCa were 66.67%, 76.19% and 85.71%, respectively; the specificity were 41.79%, 43.28% and 68.66% . (F / T) / PSAD diagnosis of PCa specificity has a significant advantage (P <0.05). Conclusion The application of F / T / PSAD can effectively increase the detection rate of PCa in the range of 4 ~ 10ng / ml PSA, effectively reducing unnecessary biopsy.