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目的探讨不同原发位置结直肠癌伴转移患者的化疗效果。方法选取2011年1月至2016年9月间泰州市人民医院收治的84例行一线化疗的结直肠癌伴转移的患者,按肿瘤原发位置分为回盲肠组11例,升结肠组15例,横结肠组9例,降结肠组20例,直肠组29例。比较各组患者采用不同化疗方案的临床疗效及总有效率。结果患者化疗总有效率为29.8%。原发于回盲部、升结肠、横结肠、降结肠和直肠的转移性大肠癌患者,化疗有效率分别为18.2%、26.7%、22.2%、40.0%和31.0%,各组间比较,差异有统计学意义(P<0.05)。不同原发位置患者接受以奥沙利铂和伊立替康为基础的化疗方案治疗,疗效之间比较,差异有统计学意义(P<0.05),接受氟尿嘧啶和亚叶酸钙化疗的不同原发位置患者的疗效比较,差异无统计学意义(P>0.05)。原发位置在横结肠的转移性大肠癌患者,接受以伊立替康为基础的化疗方案,疗效明显优于其余两种化疗方案,差异有统计学意义(P<0.05)。结论不同原发部位转移性结直肠癌一线化疗的疗效存在差异。
Objective To investigate the effect of chemotherapy in colorectal cancer patients with metastasis at different primary sites. Methods From January 2011 to September 2016, 84 patients with colorectal cancer with metastasis undergoing primary chemotherapy in Taizhou People’s Hospital were divided into 11 cases of ileocecal group and 15 cases of ascending colon group , Transverse colon group 9 cases, descending colon group 20 cases, rectum group 29 cases. The clinical efficacy and total effective rate of different chemotherapy regimens were compared among groups. Results The total effective rate of chemotherapy was 29.8%. The primary chemotherapy in patients with metastatic colorectal cancer with ileocecal, ascending colon, transverse colon, descending colon and rectum was 18.2%, 26.7%, 22.2%, 40.0% and 31.0%, respectively Statistical significance (P <0.05). Patients in different primary sites received oxaliplatin and irinotecan-based chemotherapy regimen, the difference was statistically significant (P <0.05), receiving fluorouracil and leucovorin chemotherapy in different primary sites The efficacy of the patients, the difference was not statistically significant (P> 0.05). Patients with primary colorectal metastatic colorectal cancer receiving irinotecan chemotherapy were significantly better than the other two chemotherapy regimens (P <0.05). Conclusions There are differences in the efficacy of first-line chemotherapy for metastatic colorectal cancer with different primary sites.