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目的 :为了研究十全大补汤对免疫抑制小鼠的免疫功能的影响。方法 :以环磷酰胺造成免疫抑制小鼠模型 ,分别给予 10 0 %和 5 0 %的十全大补汤灌胃 ,0 .5ml/只 /d ,以HA、外周血WBC和脾指数作为检测指标。结果 :10 0 %和 5 0 %的十全大补汤均可明显提高小鼠HA水平及小鼠外周血WBC数目 ,且 5 0 %和 10 0 %的十全大补汤可使脾重及指数明显下降 ,水肿减轻 ,与环磷酰胺对照组相比P <0 .0 5。结论 :十全大补汤可明显改善化疗药物的副作用 ,提高小鼠的特异性抗体产生水平及脾指数
Objective: To study the effect of Shiquan Dabu Decoction on immune function in immunosuppressed mice. Methods: Cyclophosphamide-induced immunosuppressive mouse model was given with 100% and 50% Shiquan Dabu Decoction by intragastric administration, 0.5ml/d/d, and HA, peripheral blood WBC and spleen index were detected. index. Results: 10% and 50% of Shiquandabu Tang can significantly increase the level of HA in mice and the number of WBCs in peripheral blood of mice, and 50% and 100% of Shiquandabu Decoction can make spleen weight and The index decreased significantly, and the edema decreased. Compared with the cyclophosphamide control group, P<0.05. Conclusion : Shiquan Dabu Decoction can significantly improve the side effects of chemotherapeutic drugs, increase the specific antibody production level and spleen index of mice.