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AIM: To study the antipsoriatic, anti-inflammatory, and analgesic effects of ethanolic extract of red propolis. METHODS and RESULTS: This extract induced the formation of granular layer in the mouse tail test used as a model of psoriasis. Propolis 50 mg·kg-1 ig showed anti-inflammatory activity in the cotton-pellet granuloma assay in rats, in croton oil-induced edema in mice at a dose of 25 % (2.5μL), and in the peritoneal capillary permeability test in mice at a dose of 10 mg·kg-1. The extract (25 mg·kg-1 ig) showed analgesic effect in the model of acetic acid-induced writhings, whereas 40 mg·kg-1 was effective in the hot plate test in mice. CONCLUSION- Anti-inflammatory, analgesic, and antipsoriatic properties of Cuban red propolis were evident.
AIM: To study the antipsoriatic, anti-inflammatory, and analgesic effects of ethanolic extract of red propolis. METHODS and RESULTS: This extract induced the formation of granular layer in the mouse tail test used as a model of psoriasis. Propolis 50 mg · kg -1 ig showed anti-inflammatory activity in the cotton-pellet granuloma assay in rats, in croton oil-induced edema in mice at a dose of 25% (2.5 μL), and in the peritoneal capillary permeability test in mice at a dose of 10 mg · kg-1. The extract (25 mg · kg-1 ig) showed analgesic effect in the model of acetic acid-induced writhings, while 40 mg · kg-1 was effective in the hot plate test in mice. CONCLUSION- Anti-inflammatory, analgesic, and antipsoriatic properties of Cuban red propolis were evident.